Tag Archive for: stress hormones

Distress Is Normal!

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We’ve experienced ever-present stress over the past three years, from pandemics to politics to prices of just about everything. It hasn’t slowed down, and that can take its toll—if you let it. Am I saying that stress is normal? I already said that in the last Memo. The objective is to train the body to adapt to stress.

I’m not going to review the entire general adaptation syndrome, but put simply, you expose yourself to a planned stressor, such as exercise, to train the body to adapt to the hormones released during stress. That way the body is trained to respond to stress hormones when you’re exposed to other types of stress.

The Stress Response

The most extreme yet common example of the stress response I can think of for almost everyone would be this: did you ever almost have a car accident? I mean within seconds, you’d have been severely injured and maybe dead. Remember that first minute afterward? If you had sensors to test yourself, your heart rate and blood pressure would be sky high. You’d be breathing heavily. You’d most likely be shaking. All the hormones that caused those reactions would still be coursing through your body; it would take time for your body to normalize. That’s the extreme, fight-or-flight, type of stress response.

When you exercise regularly, you train your body to deal with that hormone surge, although the results aren’t as extreme as when you’re exposed to life-threatening stress. How you respond is at least partially in your control.

Dealing with Stress

I interviewed psychologist Evan Parks again to ask him how a person can deal with the anxiety caused by today’s stress. Here are his recommendations:

  • Stand outside your body and take a survey of what’s going on. Is there anything you attribute the symptoms to? Are you feeling stress in response to something specific, or is it just a general feeling of anxiety?
  • Does talking about it with a spouse or a friend help clarify things for you?
  • Can you center your thoughts from doom and gloom to a realistic perspective by prayer or meditation?

If these steps help, great. If not, it may be time to seek professional help.

Psychology isn’t my area of expertise. You can hear the interview in Straight Talk on Health on drchet.com if you’re an Insider or Member; it will be posted no later than Monday. Dr. Evan Parks does a great job of explaining all of it in more detail.

The Bottom Line

Distress is normal, so you’d better get used to it. One way to do that is to use a positive stressor such as exercise to help you prepare your body. Yes, eating a better diet and eating less may help as well. Use planned distress to your advantage by preparing your body for the unpredictable stress of today’s life.

What are you prepared to do today?

        Dr. Chet

Can Fasting Reduce Inflammation?

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In this Memo, I’ll review the third paper from the recent journal Cell on fasting and summarize what this all may mean for the use of intermittent fasting.

Researchers used both mice and humans as subjects in a series of studies. The objective was to examine how the immune system responded to a fasting protocol. For the study in humans, the subjects fasted for 19 hours after eating, with blood samples taken before and after the fast. In the mice, a variety of protocols were used. The most common was mice were fed for a short time before food was withheld for the remainder of 24 hours.

In mice and humans, circulating monocytes were reduced. This was important because they were pro-inflammatory in nature; thus inflammation decreased in response to the fasting protocol. In some of the studies, this reduction was maintained even with exposure to pathogens. That means the immune response was not compromised even in animals with induced autoimmune diseases.

Fasting Protocols

Three different studies used at least three different approaches to fasting. In the first study, food was withheld completely for 36 hours. In some phases of the second study, calories were reduced by 50% although the vitamins, minerals, and protein were maintained at normal levels. The final study used a fasting protocol we’re most familiar with: eat within a few hours and liquids only the remainder of the day.

The results were similar in sustaining and perhaps improving the immune system of the animals when placed under pathogenic stress. The only issue is what form of dietary restriction worked best? You can’t ask mice how they felt; you can only check immune system markers. In one of the approaches, the skin of the mice was injured at different times of continued fasting. The healing ability continued until the fast went beyond 48 hours; after that wound-healing was impaired.

The Bottom Line

These studies haven’t changed my approach to fasting. If you’re going to fast to rejuvenate your immune system, don’t play games. Reduce caloric intake to 500 to 800 calories per day for two to three days; those studies show the best benefit. Be sure to select small quantities of the healthiest foods.

Fasting is not abstinence. The current approaches to intermittent fasting are really intermittent abstinence. The idea is to abstain from food completely for 12 to 18 hours while still drinking liquids. That may not be possible for everyone. Some medications have to be taken in relation to food intake. Pre-diabetics and type 2 diabetics should still monitor blood sugar, especially if exercising during the fasting times. The current intermittent fasting approach is more about controlling when you eat than anything else, and that’s something you should do anyway.

I believe in fasting. That’s why I wrote Real-Life Detox—so you could do it right and gain the most benefit. The critical thing is to find a way to eat that you can sustain for the rest of your life, and that includes occasional fasts.

Eat less. Eat better. Move more. That’s always the goal.

What are you prepared to do today?

        Dr. Chet

References:
1. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.047.
2. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.049.
3. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.050

Fasting and Memory T Cells

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The second paper from the journal Cell on fasting examined the longer term effects of fasting on memory T cells. Several species of mice were used in a variety of studies; these were complex experiments to say the least. Before I go further, a little about memory T cells.

Memory T cells are a class of T cells that remain after responding to a prior infection; they’re also created in response to vaccinations. The benefit is that if someone is re-exposed to the same or similar pathogen or toxin, the memory T cells mount a more vigorous attack than after the first exposure.

The mice were monitored for two weeks to establish a baseline caloric intake, then they were maintained on 50% of their caloric intake for three weeks or longer. There were several experiments. In some, while the calories were reduced by 50%, protein, vitamins, minerals, and essential amino acids were maintained at 100%. Therefore, there were no micronutrient or protein deficiencies, just calorie deficits.

The researchers found that stress hormones increased in response to caloric reduction. The memory T cells were transported and stored in the bone marrow. When the diet was returned to normal, the memory T cells were returned to their typical locations in the immune system. Other experiments showed that the memory T cells had an enhanced ability to fight pathogens.

One more study to examine on Saturday.

What are you prepared to do today?

        Dr. Chet

References:
1. Cell 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.049.
2. Translational Biology in Medicine, 2014.