Tag Archive for: muscle

Is High Protein Intake Associated with Sarcopenia?

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If there’s one thing I’ve learned studying health, fitness, and nutrition for 35 years, it’s this: what we thought we knew yesterday may change based on what we learn today. Given that, I was still surprised to see an article in my news feed with a title “High Protein Intake Associated With Sarcopenia.” The Taking Back Your Muscle webinar uses strategies that research has shown help increase muscle strength, including eating more protein. What gives with this latest research?

Researchers selected as their subjects from the TwinsUK cohort. Subjects must be over 60 years old and have completed specific tests since 2010. Just over 3,300 men and women were selected to be included in the data analysis. Researchers examined a variety of variables including education, income, other diseases and conditions, strength, and muscle mass. Protein intake was measured. Researchers did find the opposite of what they expected: higher protein intake was associated with sarcopenia.

Did I get it wrong? I’ll talk about the rest of the study on Saturday. I wouldn’t change your protein intake just yet because there seems to be a larger problem that looms over us as we age. The article is open access, and you can read it at this link.

What are you prepared to do today?

        Dr. Chet

Reference:https://academic.oup.com/ageing/article/52/2/afad018/7036280

Aging Stressor: The Muscular System

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Sarcopenia is the number one issue that impacts muscles—that’s the loss of skeletal muscle mass and strength that comes with age. It can begin as early as the 20s in some and accelerates once we pass 60; it’s thought to be primarily due to the genetics of aging. There’s also little question that a sedentary lifestyle contributes to muscle loss. Losing muscle mass impacts not just strength, but also stamina, posture, balance, and the ability to move your body.

There are several types of muscle fibers, but they all appear to become slow-twitch fibers as we age. And they get smaller. However, and this is important, they don’t ever seem to go away completely. Strength training has been shown to be effective even for people who are 100 years old; they get stronger, which helps deal with all those issues I mentioned before. The research hasn’t demonstrated that muscles will get larger, but most studies end at three to six months, which is too soon to really judge results; it’s probably going to take more than six months to gain back what we lost over many decades.

The key to dealing with sarcopenia is strength training—the earlier in life the better, but it’s never too late. Strength training can encompass many approaches from doing squats by standing up from sitting in a chair (using a walker if balance is an issue), push-ups and other calisthenics, and weight training using bands, tubes, machines, and free weights.

There are hundreds of programs and thousands of exercises to help build strength using every modality. I think it should all begin with an evaluation by a healthcare professional to test posture and balance, as well as strength. The next step is to see a physical therapist who can evaluate your limitations and put together a plan to get you started safely; it’s hard to keep your positive attitude if you get hurt right away and need to pause. Once you get approval and a plan to train, then getting muscles prepared is important. Calisthenics, which include chair exercises for those with arthritis, are a good place to begin.

Final memo before Christmas on Tuesday with one more place to attack when we’re aging with a vengeance.

What are you prepared to do today?

        Dr. Chet

Should You Increase Your Essential Amino Acids?

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The question from Tuesday was this: how did the essential amino acids affect the transgenic tau mice on the low-protein and normal-protein diets? The addition of EAA to the transgenic mice on either diet appeared to neutralize the impact of the genetic mutation. The brain scans appeared to mimic the scans of the control mice fed either type of diet. There were positive changes in the genes impacted by the EAA supplementation as well as on neurotransmitters and other biochemicals.

Before we get too excited, a couple of facts.


Mice Are Not Humans

The results of this study are exciting when we consider brain health, but this was a study on rodents—the applicability to us as humans may be limited. What is encouraging is that when the same research group did a study on humans with EAAs, they found improvement in attention and cognitive flexibility. They’re now doing a study specific to the aging brain in human subjects similar to this one on rodents. It will be interesting to see what happens when it’s published.


EAAs Are Not All Equal

The EAA blend in this study was slightly different than what is typically offered. The company providing the EAAs for the study included high amounts of phenylalanine, almost the same amount as leucine which seems to always be found in the highest amount. Does that make a significant difference? Phenylalanine is important in the manufacture of signaling proteins. Might that be important for neurological benefits? We just don’t know yet. On top of that, there’s a small percentage of people with a genetic inability to process phenylalanine very well, so they would probably have to avoid higher amounts.


The Bottom Line

While this research update is interesting, there’s still a lot to learn about the use of EAAs for neurological benefit. I’ll keep an eye on it.

However, the research on EAAs and increasing muscle is solid; there’s little question about the benefit of keeping protein intake higher to retain muscle mass as we age. The critical factor is to be consistent, because digestive issues and satiety issues can sometimes derail good intentions. If it helps our brains as well, that’s a bonus at this point.

Tomorrow is the last day of the 25% off sale on Supplementing Your Diet as either a download for yourself or CDs to share with others, and that’s in addition to Member and Insider discounts.

What are you prepared to do today?

        Dr. Chet

Reference: Science Advances. Oct 2021. (7) 43. DOI: 10.1126/sciadv.abd5046

New Research Links EAAs and Brain Function

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I’ve talked about essential amino acids in the past as it relates to increasing muscle mass in those of us 50 and older. A recently published study may give us another reason for taking essential amino acids: it may reduce, delay, and perhaps reverse neurological signs of dementia.

To understand the research, you have to know about tau: it’s a structural protein found in nerve cells that help stabilize them, and deterioration of tau is associated with the development of Alzheimer’s disease. Researchers in Japan examined the response to normal and reduced protein intake both with and without supplemental essential amino acids in mice susceptible to developing high levels of tau (rTg4510 mice) along with control mice. They used a variety of tests to determine outcomes including brain scans, biochemical analysis, and genetic expression.

Because the data from the brain scans are so visual, they’re the easiest to assess. In the controls, there was very little impact of the 5% versus 20% protein diet in the cortical area. However, in the tau mice, there was evidence of decline in brain matter with normal protein intake, but the decline was much greater in those with reduced protein intake.

We’ll examine the impact of supplementation with essential amino acids in Saturday’s memo. One thing is certain: it’s important to increase protein intake to at least 20% of calories as we get older. Regardless of your age, it might be a good idea to monitor your protein intake by all sources this week.

Reminder: you have the rest of this week to take advantage of the 25% off sale on Supplementing Your Diet as either a download for yourself or CDs to share with others, and that’s in addition to Member and Insider discounts.

What are you prepared to do today?

        Dr. Chet

Reference: SCIENCE ADVANCES. Oct 2021. (7) 43. DOI: 10.1126/sciadv.abd5046

What Is the Proteome?

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In the week we took off, I spent my time researching a couple of fascinating studies. We all have different ideas of what’s fun, don’t we? For me, getting to research topics in depth is a refreshing opportunity to learn something new. I’m going to share part of what I learned in the next several memos and it’s all about the proteome.

Obvious question: what is the proteome? A proteome is the complete set of proteins expressed by an organism—same idea as the microbiome, but with proteins instead of microbes. That includes obvious proteins such as muscle, hormones such as insulin, or many of the thousands of enzymes and other proteins the body makes. Those proteins may be produced only during specific circumstances and in response to events within and outside the body. The proteins can be systemic or they can occur in individual tissues and cells.

More than what, why is the proteome important? Research has demonstrated that there’s variability in the proteome at specific times during life. The idea is to identify which proteins change and which ones are associated with a healthier life. That’s the first step and I’ll cover a study that did just that on Saturday.

Tomorrow is the monthly Insider conference call. Check out the membership and if you become an Insider before 8 p.m. Wednesday, you can take part.

What are you prepared to do today?

        Dr. Chet

Reference: Aging Cell. 2018;17:e12799. https://doi.org/10.1111/acel.12799

Should You Take Essential Amino Acids Before Surgery?

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Tuesday’s study left us with a question: what could explain essential amino acids (EAAs) increasing, or at least preventing, muscle loss after total knee replacement surgery? Fortunately, another study examined those factors by obtaining muscle biopsies and blood before and after surgery.

Researchers recruited 41 patients who were having total knee replacement. After randomly assigning them to placebo or experimental group, the experimental group received 20 grams of EAAs twice daily, beginning seven days prior to surgery, until six weeks after surgery. Those in the placebo group were given nonessential amino acids. Muscle biopsies were collected from all subjects the day of the surgery and again either one or two weeks post-surgery with the determination made randomly. Blood was also collected for analysis at the same times as the biopsies.

The researchers found that the subjects taking the EAAs had a significantly increased amount of satellite cells, also known as muscle stem cells that can develop into muscle cells, compared to the placebo group; the ability to build muscle faster could help the recovery process. IL-6 and TNF-alpha were elevated post-surgery in both groups; however TNF-alpha declined by two weeks post-surgery in the EAAs group, which meant inflammation decreased. Based on the changes in cytokine production, inflammation after surgery decreased faster with EAAs than it did in the placebo group.

The researchers concluded that taking the EAAs seven days before surgery increased satellite cells on the day of surgery and promoted a more favorable inflammatory environment post-surgery. That could mean a quicker recovery from surgery and benefits during post-surgical rehabilitation.

The Bottom Line

While there’s more research necessary, I think the use of EAAs before and after knee replacement surgery is helpful. I would extend that even further; I think that EAAs may ultimately prove to be beneficial before and after any type of surgery. In almost every case, muscle tissue is going to be cut and thus will need to repair itself. We don’t know the benefits of EAAs on other connective tissue such as skin and ligaments, but because we’re targeting the key elements of protein with the EAAs, there’s little to no chance of any harm.

Based on these two studies, I think that 10 to 20 grams, spread out in two doses per day, would be the best approach. One important point: take the EAAs 15 to 30 minutes before eating anything or before working out. Those were the protocols used, and it’s the same that I recommend in Aging with a Vengeance for increasing muscle mass as we age.

I’ll be honest: it tastes weird. But I made sure Paula took EAAs before and after her recent carpal tunnel surgery, so you know I think it’s worth the effort.

What are you prepared to do today?

        Dr. Chet

Reference: J Appl Physiol (1985). 2019 Aug 1; 127(2): 531–545.

Improve Your Posture

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Today is the final post about the physical factors of living and not just being alive, and it’s about your posture, the way you carry yourself. Posture reflects the interplay of your skeletal, muscular, and nervous system: the way you stand, the way you move, and the way you sit. Those all rely on the interaction of the three systems. The key is that we have to train those systems to consciously respond to the way we want to stand or sit until they become automatic.

I was overweight as a kid. One of the things I did was hold my stomach in so I didn’t appear to be so fat. It stuck. I don’t know what it’s like to relax my abs because it seems unnatural to do so. Here’s a secret: you can look five to ten pounds lighter just by holding your abs in and your shoulders back. You also can be taller by training your core to keep your stomach in and training your shoulders to hold your head erect.

There’s a lot going against us. Sofas are soft to sink into, and we do. Even our car seats can make it harder to hold our shoulders back. We are always looking at our cell phones, so we see teens developing the cell-phone hump, which looks a lot like the dowager hump. And even if we stand or sit straight, it may all fall apart when we work or exercise. Do you bend at the waist to pick up a package? Do you run hunched over? Especially when you lift weights, it’s important to get the posture correct so you’re training the correct muscles in the correct movement; that’s why it’s good to have a trainer or physical therapist to help you get started. And by the way, that’s the real reason for the walls of mirrors at the gym.

How do you stand tall? Sit tall? Practice. Once you get the correct posture, you have to keep practicing it until it becomes automatic. We have to fight our nature to slouch standing or sitting. You just have to keep practicing until it becomes automatic. It can impact just about every organ in your body, including your bones. That’s where we’ll pick this up next week.

What are you prepared to do today?

        Dr. Chet

How Flexible Are You?

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Living every day you’re alive requires flexibility. Range of motion in your joints is important to your ability to move, but it can be difficult. As the years add up, touching your toes with your knees locked, whether sitting on the floor or standing, lifting your arms over your head, or even lifting your arms to shoulder level can be a challenge.

Connective tissue tends to tighten as we age; it’s another case of use it or lose it. And when I say age, I mean from teen years on. Later, after we’ve torn ligaments, sprained ankles, been in accidents, and on and on, if we haven’t worked on our range of motion, we can end up restricted in our ability to move. The less we move, the more restricted we can get.

The obvious way to increase flexibility is to stretch. There are dozens if not hundreds of programs online, but I would recommend that you get an examination by a physical therapist who can identify your strengths and weaknesses and prepare a program just for you, taking into account your current level of flexibility and previous injuries. The older you are, the more strongly I recommend physical therapy, because if you stretch too far and damage connective tissue, you’ve just made your situation worse. Another option, especially if you’re younger or more fit, is to try yoga, which is an overall muscle-strengthening and stretching program. Take a class with an experienced instructor so you can get feedback on whether you’re doing the movements correctly.

Stretching is something you should do every day. There’s one area that needs special attention and that’s your core. I’ll cover that on Thursday.

What are you prepared to do today?

        Dr. Chet

Preventing Muscle Loss

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This final installment on muscle focuses on keeping the muscle mass you’ve got. That’s one of the keys to living every day you’re alive: the ability to move at every age. There are three things that are important to hanging onto muscle.

  • Use it or lose it. Actually, you’re going to lose it not matter what, but the degree to which you will is partially dependent on using it. Whenever you can take the stairs, take them. Whenever you can lift something, lift it. While I would hate it personally, it was better when we had to get up and actually walk to the television to change the channel. More today than ever, we don’t take the opportunity to build muscle or increase stamina.
  • Exercise regularly. No matter your age, there’s always something you can do. Orthopedic issues happen as we get older—arthritis in hands, shoulders, hips, and knees, or torn ligaments and cartilages. They can all put limitations on what we can do. We have to work within those restrictions and do as much as we can to maintain and even increase what we have. A session with an excellent physical therapist (ask your doctor if you qualify for some free sessions) or certified personal trainer could be worth the money. It’s never too late to begin. Research has shown that even people over 100 years old can increase strength and stamina.
  • Consider taking essential amino acids every day. While the focus has been on what EAAs can do for people who train hard, the bulk of the research has been done on people 50 and older. It’s clear you can slow down muscle loss and increase muscle strength by exercising regularly and taking EAAs every day. I’ve been taking them the days I lift, but I’m considering taking them every day. In continuing to research the benefits, there doesn’t seem to be a downside to taking EAAs. There’s some preliminary research that indicates that taking EAAs may even be beneficial for pre-diabetics to reduce insulin levels and triglycerides if they exercise regularly as well.

The purpose for the month’s Memos is showing you how to learn to live every day you’re alive. Muscle is critical to that goal. We’ll move on to another important physical component of living next week.

What are you prepared to do today?

        Dr. Chet

Skeletal Muscle: Strength

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This week, we’re turning our attention to skeletal muscle. Skeletal muscle allows us to move and to lift ourselves and other objects. The two primary features are strength and stamina. Let’s begin with strength.

A simple definition of strength is the most weight you could lift once. That could be as little as a couple of pounds, or it could be as much a thousand pounds as some weight lifters have done. To me, as a minimum, strength is the ability to be able to do everyday tasks. We’ll start with the most fundamental, which would be sitting down in a chair or on a commode and then having enough leg strength to stand up. It would be enough to be able to lift a bag of groceries. To lift a hammer to hit a nail. To hold a hair dryer over your head while you do your hair. You can probably think of a few more.

Years ago, I mentioned to my mother-in-law that most women over 65 can’t lift 10 pounds. We lose strength as we age. She had just gotten back from grocery shopping and she picked up a 10-pound sack of flour. She began lifting it up over her head and back down to her lap and said, “Look Chet, I can do that!” She was in her mid-seventies at the time.

Strength can vary by body joints. With two torn biceps, I don’t have nearly the strength in my arms and shoulders as I used to, but I still have pretty good leg strength and pretty good back strength; my exercise routine includes strength training for all those areas.

How do you increase strength? Challenge the muscles to lift more weight than you currently can for any different set of muscles: your shoulders, your arms, your quads, your calves, and of course, there’s your core. I’ll save that for later in the month. Next time, we’ll take a look at muscular stamina.

What are you prepared to do today?

        Dr. Chet