Tag Archive for: mitochondria

Long COVID and Possible Solutions

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I had a talk with someone who had a question about a skin condition, something that’s been a minor issue but suddenly got much worse. I happened to mention that sometimes when you deal with the flu or COVID, your immune system is weakened and it can impact other conditions; people report their symptoms began to get worse after a bout of COVID, almost to the day after recovering. Cause and effect? No way to know for sure. But long COVID is a reality; long COVID is a smorgasbord of illnesses that have been somehow triggered by COVID.

Coincidentally, an article was published on the development of treatments for long COVID. While there isn’t complete agreement exactly why it happens to some but not all those who’ve had COVID, physicians and scientists are looking at combinations of medications and supplements for possible solutions. While the article focused on using the antiviral Paxlovid, I was interested in the nutrient approach—specifically, the nutrients that focus on helping the mitochondria. Whatever else may be going on in long COVID, fatigue seems to be the worst side effect of the long COVID symptoms. That has to include an impact on the mitochondria regardless of whether it’s neurological or hormonal or even genetic in nature.

While other supplements were discussed, my experience is with N-acetyl cysteine and the amino acid glycine. Research has shown that when taken together, they help with repair and recycling of mitochondria. The typical amounts are about 600 mg of each per day; I’ve taken it regularly for a few years and I’ve noticed a difference in energy levels. Talk with your physician if you have long COVID or just have fatigue. There are also meds being tested for long COVID. The rest you know: eat less, eat better, move more.

What are you prepared to do today?

        Dr. Chet

Reference: Paxlovid, Vitamin Supplements Show Promise With Long COVID – Medscape – July 29, 2024.

How Fasting Impacts Your Mitochondria

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The research scientist in the webinar focused on mitochondria and aging in his part of the presentation. He has helped research and develop a nutrient that appears to help with mitophagy, the process of removing and replenishing old mitochondria. The naturally produced chemical is called urolithin A. It’s produced naturally by the microbiome in response to eating foods such as fruit, especially pomegranate, and nuts. The problem is that we may or may not produce enough urolithin A, depending on the state of our microbiome. There has been decent research on the supplement, and I talked about the supplement in Aging with the Vengeance: Reclaiming Your Power.

What caught my attention was that intermittent fasting may also help with renewing and replenishing mitochondria. The problem becomes what kind of fasting are we talking about? Complete fasting? Eating during only a few hours per day? I’ll cover the two most popular forms.

Intermittent Fasting

Intermittent fasting is “in” right now. It is especially popular when combined with the Paleolithic or the ketogenic diet. What it essentially means is that you take in no calories by mouth for up to 20 hours per day, often called the 20:4 approach, and then you eat during that four-hour block of time. Research has shown that people lose weight, get better control of their prediabetes, and may even reduce some of the metrics related to cardiovascular disease such as blood pressure and cholesterol levels. But specific to mitochondria, the data are nowhere near as clear.

Fasting Mimicking Diet

I first encountered the fasting mimicking diet, or FMD for short, when I looked at the research of Valter Longo. He’s a scientist who has used periodic fasting with patients undergoing cancer treatment. For one to five days before treatment, they go on an FMD which drops down to 500 calories per day in some cases, and then they go back to their regular diet and go through their normal chemotherapy protocol. The critical factor is that he’s shown an improved quality of life as well as improved outcomes for people who used the FMD during treatment as opposed to those who ate their normal diet.

In research in mice, using FMD has demonstrated a reduction in symptoms of Alzheimer’s disease and dementia. Parkinson’s disease, obesity, type 2 diabetes, and others have also benefited from the FMD approach. Dr. Longo has created a commercial program that is available.

Why FMD? As near as I can gather, the concept utilizes the body’s protective mechanisms that allow energy to continue to be produced at a high enough rate to continue carrying on with life (such as searching for food in other eras) in the absence of food until food can be found. Research in athletes who’ve used FMD versus a normal diet has demonstrated maintenance of strength and endurance after going through a five-day FMD protocol while continuing to work out.

The Bottom Line

In my opinion, FMD makes sense. Fasting for two days and then going back to your normal diet for a couple of weeks just makes more sense than obsessing about when you can eat every day. But you may feel intermittent fasting’s a better way to go for your life, and that’s fine as well. One thing for sure is that I’m going to continue to follow this research.

The whole point to this is that restricting calories for long blocks of time stimulates the body to take good care of our mitochondria; that’s one battle that we have to win if we expect to age with a vengeance. And the great thing is that you can begin at any age.

What are you prepared to do today?

        Dr. Chet

2022 Super Bowl Webinar

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The first Super Bowl Webinar I did examined the energy systems of the body and how to train each one for a specific purpose, a concept called “specificity of training.” Now, 12 years later, we’re going back to examine the part of the cells that produces the most energy: the mitochondria.

Recent research has focused on what happens to mitochondria over our lifetime. Free radicals, the by-products of energy production in the mitochondria, interfere with energy production. More than that, they can damage the mitochondria, prevent the production of new mitochondria, and prevent the normal recycling of mitochondrial components to be reused in the body. The result is a lack of energy that impacts all phases of our lives.

That’s the problem. Is there any solution? That’s the topic of this year’s Super Bowl Webinar: Reclaiming Your Power! Based on the most recent research, I’m going to explain what goes wrong and the potential solutions, which include exercise, diet, and supplements. And it’s not just the over-65 crowd that may produce less energy; from early adulthood, you can start feeling the effects. No matter what your age, if you feel you don’t have the energy you used to have, join me for this year’s Super Bowl Webinar.

The webinar will be held live on Super Bowl Sunday, February 13, at 3 p.m. Eastern Time; your cost is only $12.95. If you can’t join live, you’ll get access to the replay for a week after the live webinar. Of course, Insiders and Members get the usual discounts.

If you want to reclaim your power, join me on the 13th to find out how.

What are you prepared to do today?

        Dr. Chet

I’m Back!

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It’s been an interesting five weeks since my knee replacement. I’ve never taken that much time off before, but I’m healing well—just not as quickly as I want. Researching the best way to gain back joint strength and muscle loss, I’ve come across a new term that combines two conditions: osteosarcopenia. It’s a combination of the loss of bone mass and the loss of muscle mass.

Osteopenia is the loss of bone mass. While associated with aging, other factors play a part such as genetics, lack of exercise, and poor absorption of nutrients.

Sarcopenia, loss of muscle mass, is definitely associated with the lack of exercise, but there are other factors as well. One that was surprising was the deterioration of mitochondrial function, both in number and effectiveness of function. When mitochondria can’t produce energy effectively and can’t repair and replace themselves, it can impact every cell and organ, not just muscle.

I’ve spent a considerable amount of time looking at the research to find out possible solutions to mitochondrial decline. I can tell you that one of the keys is exercise: strength training, stretching, and aerobic exercise. The rest merits significant explanation. That’s why it will be the topic of this year’s Super Bowl Webinar Aging with a Vengeance: Reclaiming Your Power! on Sunday, February 13 at 3 p.m. Eastern Time. More information to come.

What are you prepared to do today?

        Dr. Chet

Gluconeogenesis: Making Sugar

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On Tuesday, I said that blood sugars remained stable in all subjects throughout the study. How can that be when they would most likely use all their stored sugar in 24 hours or so? Their bodies made glucose out of protein and scraps from the breakdown of other substances.

Many hormones and connective tissue are made out of protein and are typically repaired after damage. The liver can use some amino acids from the damaged proteins to make metabolites that can enter the citric-acid cycle. When those remnants become scarce, the Number One source is muscle. Skeletal muscle is our protein storage facility, and while it isn’t preferred to use protein in this way, the body is protective of your blood sugar level and will protect it no matter what; it will make sugar for energy using whatever is available.

Use of fat as a fuel also increases, primarily in the mitochondria. While it’s complicated biochemistry, mitochondria are then stimulated to become more active and produce more free radicals. The good news is that researchers also observed an increase in antioxidant activity. Glutathione levels remained constant but an analog of glutathione called ophthalmic acid increased, keeping the rise in free radicals in check.

There was one more significant set of metabolites that were released. I’ll cover that on Saturday. What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1038/s41598-018-36674-9

Do You Make Enough Coenzyme Q10?

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There’s one major difference between coQ10 and other vitamins, minerals, and nutrients such as omega-3s: we can produce coQ10 ourselves. The problem is that we may not produce all the coQ10 we need, especially as we get older.

CoQ10 is used in the production of energy from both carbohydrates and fat in the mitochondria of the cells. You remember mitochondria from science class; they’re often called the powerhouse of the cells. And coQ10 is the substance that’s used to produce that power. It’s critical in the steps where oxygen is used to produce ATP, the . . .

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Drinking Your Phytonutrients: The Bottom Line

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To finish this series, I’ll briefly cover two recent research studies on coffee and tea, and then give you the bottom line and a recipe.
 
Research
Green Tea and Neuronal Mitochondria
The mitochondria are the powerhouses of the cells, and that includes brain cells. When they operate at peak activity, they provide our brains with the energy for learning and memory. The downside is that they produce many free radicals in the process, and if we don’t have antioxidants to quench those free radicals, it can cause a decline in mental function. Researchers have recently . . .

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Taurine and Energy Drinks

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Taurine is typically found in energy drinks, but many people don’t understand how it works. Let’s start with the obvious: how could taurine help with increasing energy levels in the body?

In a review article, the authors explained the role of the beta-amino acid taurine in energy production (1): not supplying calories, but having a role in the production of energy inside the mitochondria, the powerhouse of the cell. It’s an extremely complicated biochemical process, but let’s see if we can break it down into simpler terms.

Taurine contributes to the production of proteins inside . . .

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