The question from Tuesday was this: how did the essential amino acids affect the transgenic tau mice on the low-protein and normal-protein diets? The addition of EAA to the transgenic mice on either diet appeared to neutralize the impact of the genetic mutation. The brain scans appeared to mimic the scans of the control mice fed either type of diet. There were positive changes in the genes impacted by the EAA supplementation as well as on neurotransmitters and other biochemicals.

Before we get too excited, a couple of facts.

Mice Are Not Humans

The results of this study are exciting when we consider brain health, but this was a study on rodents—the applicability to us as humans may be limited. What is encouraging is that when the same research group did a study on humans with EAAs, they found improvement in attention and cognitive flexibility. They’re now doing a study specific to the aging brain in human subjects similar to this one on rodents. It will be interesting to see what happens when it’s published.

EAAs Are Not All Equal

The EAA blend in this study was slightly different than what is typically offered. The company providing the EAAs for the study included high amounts of phenylalanine, almost the same amount as leucine which seems to always be found in the highest amount. Does that make a significant difference? Phenylalanine is important in the manufacture of signaling proteins. Might that be important for neurological benefits? We just don’t know yet. On top of that, there’s a small percentage of people with a genetic inability to process phenylalanine very well, so they would probably have to avoid higher amounts.

The Bottom Line

While this research update is interesting, there’s still a lot to learn about the use of EAAs for neurological benefit. I’ll keep an eye on it.

However, the research on EAAs and increasing muscle is solid; there’s little question about the benefit of keeping protein intake higher to retain muscle mass as we age. The critical factor is to be consistent, because digestive issues and satiety issues can sometimes derail good intentions. If it helps our brains as well, that’s a bonus at this point.

Tomorrow is the last day of the 25% off sale on Supplementing Your Diet as either a download for yourself or CDs to share with others, and that’s in addition to Member and Insider discounts.

What are you prepared to do today?

        Dr. Chet

Reference: Science Advances. Oct 2021. (7) 43. DOI: 10.1126/sciadv.abd5046