Tag Archive for: longevity

Aging with a Vengeance and Your Proteome

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This year’s Super Bowl Webinar focused on aging with a vengeance—becoming the best version of yourself, no matter your age. The study we just reviewed on the proteome suggests that the people were healthier who were biochemically younger than their actual age. Here are the actions I believe can help at the three critical phases of aging that were identified in proteome study. As I find out more, I’ll be more specific.

31 to 37

If you have weight to lose, now is the time to lose it. Take it from me and my decades of experience with weight loss programs: it becomes more difficult the older you get. Find a way to eat that will maintain a reduced body weight and stick with it.

Reduce your protein intake. That may seem a little odd, but this is a time to focus on vegetables, fruit, whole grains, and quality oils.

Focus on your cardiovascular system by doing aerobic exercise on a regular basis. Use interval training to make the most of your time, and when you’re fit enough, you can add high-intensity interval training (HIIT) to your routine.

57 to 63

The kind of 80- to 85-year-old you’re going to be is dependent on what you do now. If you haven’t achieved a normal body weight, that’s a high priority just as it was in the prior age group. I know how difficult this is because it’s eluded me throughout my life; I lost a lot of weight and kept it off for years, but I’d still like to weigh less.

Increase protein intake to 1–1.5 grams per kilogram body weight per day.

Supplement your diet with essential amino acids. While the amounts are still not absolutely clear from the research, 10–20 grams per day is a good goal.

If you’re not already doing so, add weight training to your exercise routine. Start with using your own body weight, then add exercise tubes or light weights, and then use machines or free weights. Now is the time to retain or even increase your muscle mass.

75 and Older

If you haven’t achieved a normal body weight, there’s still time. My wonderful mother-in-law lost a significant amount of weight at this age, and she was an overweight diabetic in a wheelchair.

Increase protein intake to 1.5–2 grams per kilogram body weight per day. It’s difficult because appetite decreases and protein makes us feel full. It will help reduce the muscle loss that’s happening.

Supplement your diet with essential amino acids; the amounts are still between 10–20 grams per day.

Add weight training to your exercise routine. It will help you to retain or even increase your muscle mass. Stay within any orthopedic or other limitations, and get some help if you need to, but do it. Your primary caregiver will probably be glad to refer you to a physical therapist who can get you started safely.

The Bottom Line

For all that’s been written about healthy aging, we still don’t know very much. Healthy aging begins the day we are born, but we realize that only when it dawns on us that we’re aging. No matter your age, no matter your current state of health, it can be better. You can learn more in the replay of this year’s Super Bowl Webinar, but it will be available for only a little while longer.

The simple things I’ve talked about in this Memo are a beginning. When I know more, so will you. Inevitably, it comes back to a single question:

What are you prepared to do today?

        Dr. Chet

Reference: Nature Medicine. 2019. https://doi.org/10.1038/s41591-019-0673-2

Proteome: Predicting Your Age

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Have you ever taken a test or questionnaire that predicts your health age? What they’re really predicting is your longevity based on lifestyle factors and where your health stands today. What if you could be more precise in actually calculating your health age? That’s what researchers did based on the results of the proteome study I talked about last week.

The researchers identified 373 proteins that could be used to predict someone’s age within about three years. They used proteome data from other studies to test the predictive capability. When the test predicted people were younger than they actually were, those people did better on cognitive and physical tests. That means the proteome was revealing a pattern of proteins associated with someone who was younger.

Don’t run out to get this test; it isn’t available—yet. Scientists are working to narrow the proteins included in the age-predictive equation; there’s a lot of work to be done before it can have any clinical significance.

Does that mean there’s nothing we can do now, test or no test? I think we have some options, and I’ll tell you about that Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: Nature Medicine. 2019. https://doi.org/10.1038/s41591-019-0673-2

Genetics or Lifestyle?

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My dad died of a heart attack when he was 41. That fact has always been hanging over my head, especially when I had a heart blockage 16 years ago; the coronary artery was opened, I had a stent put in and have had no issues since. Was it my genes or was it lifestyle? Genotype or genes versus phenotype or lifestyle. I’ve always said genes, but not any more.

Researchers recently published an analysis of over 800 million individuals after examining births, deaths, and relationships between the individuals: in other words, who married whom, how many children they had, how long they lived. They found that a role for a genetic component of longevity was supported in family trees of people who were related. But here’s the interesting thing: they also found that there was a longevity relationship between non-blood relatives as well. In other words, the subjects’ in-laws shared similar traits for longevity.

What does that mean? Perhaps people unconsciously select mates with comparable traits. Because we don’t do that intentionally by genetics, it means that similar environments have a similar impact.

The actual role of genetics was estimated to be well below 10%. In other words, phenotype or lifestyle is more meaningful than your genes for how long you live. This was a very complicated mathematical analysis, so we should proceed with caution, but there’s little question that lifestyle has more to do with longevity than your genes.

Good genes give you a good start, but what you do after that matters most. What should you do? Eat better. Eat less. Move more.

Your body. Your choice. What are you prepared to do today?

Dr. Chet

 

Reference: https://doi.org/10.1534/genetics.118.301613

 

How to Live to Your 90s

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Today’s message is based on my father-in-law, Don Jones, or Joner as most of us knew him. As I said Wednesday, he passed away last Sunday. He lived to 94 years and six months; Peggy, the sister he was closest to, died at the exact same age. How was he able to live that long? I’ll give you my observations based on his life.

  • Genetics: it pays to have the right genes and Dad certainly did. Several of his siblings lived into their 90s.
  • Quit smoking: he quit smoking before he turned 21 years old. That’s probably the single most important thing he did. His father and siblings who smoked all died much younger. He never drank alcohol after that either.
  • Love: he loved his wife of over 70 years deeply, and as I said Wednesday, he longed to be with Ruth again. That’s a love that transcends life itself.
  • Humor: he had a great sense of humor. He gave it and was able to take it as well. My big ears were a frequent target. Once after we came in from a run together on a cold day, he said, “I know why you wear that headband: reduce wind resistance.”
  • Demeanor: he was almost always calm and pleasant and rarely showed any anger. Paula said when she was a kid and acted up, he’d just hang his head and sigh, and that hurt worse than any spanking. Once when he was mad at me, he showed it by leaving the newspaper at the top of the steps instead of putting it on the counter. He never stayed mad long.
  • Faith: he believed in God and lived his faith.
  • Exercise: he worked physical jobs most of his life. Then he began running when he was 70 and continued until he was in his mid-80s, hitting 700 miles for 2002. No doubt that helped him live longer than he might have with a genetic tendency toward stroke. He was never very fast but once you’re over 70, there’s not a lot of competition and he enjoyed picking up trophies at many of his 5Ks. I’m sure that competitive spirit added zest to his life.
  • Body weight: he was never fat for his height. That reduced any additional stress on his joints.

Those are my observations on how Joner lived into his 90s. While you can’t change your genes, you can certainly make the most of what you’ve got; his lifestyle and approach to life certainly helped my father-in-law.

What are you prepared to do today?

Dr. Chet

 

I’m Alive V2.48

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When I opened my eyes this morning, I said the same thing I’ve said for the past 24 years: I’m alive! I’ve come to believe that if I wake up this morning, it means I have at least one more year. It makes no sense, but I can’t change the way I think about this one thing.

The question is why. My dad died 48 years ago today at the age of 41. Ever since I opened my eyes on May 10th when I was 41, I believed I would live another year. Again, it makes no sense but it’s what I believe. For the many new subscribers, now you have a little insight into how I think.

This year also has a similar message to the one from three years ago. My father-in-law, Don Jones (Joner to most of us), passed away on May 7 at the age of 94. It was three years to the day and almost the same time of day as my mother-in-law, Ruth Jones. While we most definitely will miss him and all his stories, we’re not sad. His body had let him down the past couple of years; I think he decided it was time to go be with his Ruthie again and he just quietly slipped away. How can you be sad about that? They were together on this earth for over 70 years and now they have eternity. That deserves a celebration.

Whether it’s a day, a month, a year, or until I’m 94, I’ve got a lot to do to help you get healthy and fit to be able to live life the way you want to live it. Stay tuned because we’re just getting warmed up.

What are you prepared to do today?

Dr. Chet