Tag Archive for: genetics

Why I Hate Cilantro

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The All of Us genetic testing results I told you about Tuesday included four more genes; by examining the results, these genes explain a lot about my personal tastes. These are not world-changing genetic analyses such as risk for cardiovascular disease or celiac disease, but they’re nevertheless interesting. Here’s what else I found out about myself from the results.

Bitter

Remember, there are five tastes: bitter, salty, sour, sweet, and umami. Evidently not everyone tastes foods the same way; I didn’t know that there are at least 25 different types of bitter receptors. I have a gene that allows me to taste flavors that are considered bitter. There are at least 550 foods identified as bitter; some I naturally like such as coffee. We can adapt to tastes regardless of our genes, so you may develop an appreciation of bitter foods if you don’t like them now.

Earwax

I have a normal gene that allows me to produce wet earwax as opposed to dry, flaky earwax. In the analysis I received, there’s a long explanation about earwax and what it does. One function of earwax is to keep the ear drum dry when water enters the ear canal; it made me wonder if that’s why some people are more prone to “swimmer’s ear” than others.

Lactose Intolerance

There’s a gene that, depending on its location on your DNA, will allow you to produce more lactase, the enzyme that breaks down the milk sugar lactose. If the gene is in a different position, you may lose your ability to produce enough lactase, and thus you become lactose intolerant. Mine is evidently in a good position because I digest dairy products just fine.

Cilantro

I have the “I hate cilantro” gene. Actually, that’s an overstatement. If you have the gene mutation, you have a slight chance of disliking it, somewhere between 3% and 21%. To me (and Paula), it strongly tastes like soap instead of the refreshing citrus flavor most people experience.

Those were the genetic results I’ve gotten so far—nothing earth shattering but interesting nonetheless. It explains a lot, including that in spite of your genes, you can overcome some of your genetic tendencies and learn to love cilantro.

Consider joining the All of Us Research Program. You’ll be contributing a lot and you just might learn some interesting things about your genes as well. Check it out at https://www.joinallofus.org//#.

What are you prepared to do today?

        Dr. Chet

All of Us: Genetic Results

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Almost two years ago, I wrote about the All of Us Research Program. Their goal was to get 1,000,000 partners who would be subjects in the largest study ever done within the U.S. I decided to participate fully and that means answering questionnaires as well as giving blood samples and other basic health information. I’ve gotten some results but this past week, I finally got some of the analysis of my DNA and genetics.

Paula likes to call me a pure-bred: all of my ancestors were Polish (with the exception of one maternal great-grandfather), while her ancestors came from all over Europe. While I was curious what the ancestry portion of the DNA test would reveal, there wasn’t much doubt. The All of Us program goes through great pains to explain why some people might want to know their ancestry while others might not. I would describe it as fairly rigorous just to make sure that you really, really wanted to know the outcome.

My DNA confirmed that there was a 79% chance that I was from Eastern Europe, specifically Poland or the Ukraine. The rest of the probability was northern or western European. No great surprises there. They also tested for four other genes, and I’ll talk about those on Saturday.

They’re still looking for participants. I would urge you to go to https://allofus.nih.gov/ and be part of something greater than yourself. You might also find out why you love cilantro or think it tastes like soap.

Super Bowl Webinar Replay

If you missed out on the webinar, you can still watch it in its entirety by purchasing the replay. It was the kick-off event for longer term focus on helping you become the best version of yourself. Aging with a Vengeance is just the beginning; you’ll see more as the year goes on.

What are you prepared to do today?

        Dr. Chet

Should Your DNA Guide Your Diet?

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In an opinion piece, a college professor in the U.K. who had written about personalized nutrition wanted to find out whether she should change her diet based on her genetic profile. She decided to send her DNA to Norway for analysis.

Her genetic profile indicated that she was at risk for having high cholesterol and an increased risk for cardiovascular disease. To deal with that, she became a vegetarian. She also takes high levels of B vitamins because she doesn’t process one of the B vitamins very well. Her point was that knowing her genetics gave her the motivation to take control of her diet and lifestyle. She now advocates that all of us should take control of our health through personalized nutrition based on our DNA analysis.

I’m not so sure. I think genetics are one piece of a complex puzzle. What causes the genes to express themselves? What turns them off? More than anything, what role does the microbiome play when combined with the genes? We still don’t know the answers to any of those questions.

Someday we may be at a point where we can be very specific about nutrition, but we’re not there yet because we not only don’t know the answers—we don’t know the correct questions to ask. For reliable results, it still comes down to what I always tell you: Eat better. Eat less. Move more.

What are you prepared to do today?

        Dr. Chet

Reference: http://bit.ly/2ZclpII

Something Greater than Yourself

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Who’s going to analyze all of this data when data collection is complete? A better question might be who couldn’t analyze this data. The answer: anyone who has a good research question and agrees to abide by the guidelines of data usage can run an analysis. That could even be you. That’s correct; if you have a question and the ability to analyze the data, you could do it.

The goal is personalized medicine, and not just a pitch by a practice that’s talking about typical healthcare. The goal is to be able to identify the subgroups that will respond best to preventive health practices or to specific disease treatments. In that way, a profile of the best techniques based on genetics, environment, and lifestyle can be developed.

The only disappointment I have is that they didn’t include the microbiome. That would require a stool sample and add a greater degree of complexity to a data collection procedure that’s already very complicated. Maybe they’ll add that in the future.

If you go to the All of Us website, you’ll be able to find the local healthcare system in your area that’s responsible for data collection. In Grand Rapids, it’s Spectrum Health. I did the surveys online and scheduled an appointment for the physical data collection; that was it. In our area, we get a $25 gift card to a large grocery store chain, so I’m planning to get the whole family involved; Riley’s off the hook because you must be 18 and able to give consent. Whether you’re healthy or not doesn’t play a part in it; in fact, the info from people with current health conditions may be even more important.

The Bottom Line

The opportunity to become a part of something significant doesn’t happen all the time and almost never in preventive healthcare. This is time to do something greater than yourself, I can’t tell you whether it will benefit you personally, but it will benefit humanity. Maybe, just maybe, it will benefit a friend or relative. Check it out and check in to All of Us.

What are you prepared to do today?

        Dr. Chet

Reference: https://allofus.nih.gov/

All of Us: The Details

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Before I go further, I want you to consider this. For every variable, there will be a million data points. Height: one million. Weight: one million. Hip circumference: one million. You get the idea—and this is the simple stuff. The blood work alone could have 100 variables. Then we get into the DNA. Every gene has to be mapped to examine specific areas of DNA to see similarities or differences between healthy people and those with diseases.

If you volunteer, you will be called a partner instead of a subject. You’ll be giving the study plenty of information, but the information doesn’t just go one way. In the future, when there’s something that can benefit your health, you may be given information critical to preventing or treating a disease. The data collection includes giving Informed Consent and HIPAA for electronic data collection. Then there are several surveys and perhaps more in the future. There will also be blood and urine specimens as well as some baseline anthropomorphic data.

One thing that’s on everyone’s mind is information security. The researchers go into great detail to protect your identity. Data will be posted only with a number instead of a name, and the highest level of encryption available today will be used to protect your identity. I take security seriously, and I’m comfortable with it.

Check out the link in the Reference to find out more, and if you choose, to get started now yourself.

What are you prepared to do today?

        Dr. Chet

Reference: https://allofus.nih.gov/

All of Us

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Would you like to be part of one of the largest studies ever attempted in the U.S.? I decided I would and I think you should as well.

The study is called All of Us, and it’s an attempt to gather health data from one million or more volunteers and then track them over many years. The purpose is to examine how genetics, environment, and lifestyle can impact health and disease. The goal is to provide a database that researchers can use to determine the factors that can impact the development of disease and eventually, the most effective treatment.

I think that’s the real goal. We have no idea what causes many diseases, whether it’s arthritis, cancer, auto-immune, or many others. The same holds true for treatments. Why does one treatment work well on one person and not at all on another? The genetics and environment as well as lifestyle may all have a role; with a database so extensive, just about every type of human subgroup will be represented.

What’s involved? I’ll tell you that on Thursday. If you want to read about all the details involved, check out the link in the References.

What are you prepared to do today?

        Dr. Chet

Reference: https://allofus.nih.gov/

Genetics or Lifestyle?

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My dad died of a heart attack when he was 41. That fact has always been hanging over my head, especially when I had a heart blockage 16 years ago; the coronary artery was opened, I had a stent put in and have had no issues since. Was it my genes or was it lifestyle? Genotype or genes versus phenotype or lifestyle. I’ve always said genes, but not any more.

Researchers recently published an analysis of over 800 million individuals after examining births, deaths, and relationships between the individuals: in other words, who married whom, how many children they had, how long they lived. They found that a role for a genetic component of longevity was supported in family trees of people who were related. But here’s the interesting thing: they also found that there was a longevity relationship between non-blood relatives as well. In other words, the subjects’ in-laws shared similar traits for longevity.

What does that mean? Perhaps people unconsciously select mates with comparable traits. Because we don’t do that intentionally by genetics, it means that similar environments have a similar impact.

The actual role of genetics was estimated to be well below 10%. In other words, phenotype or lifestyle is more meaningful than your genes for how long you live. This was a very complicated mathematical analysis, so we should proceed with caution, but there’s little question that lifestyle has more to do with longevity than your genes.

Good genes give you a good start, but what you do after that matters most. What should you do? Eat better. Eat less. Move more.

Your body. Your choice. What are you prepared to do today?

Dr. Chet

 

Reference: https://doi.org/10.1534/genetics.118.301613

 

How to Live to Your 90s

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Today’s message is based on my father-in-law, Don Jones, or Joner as most of us knew him. As I said Wednesday, he passed away last Sunday. He lived to 94 years and six months; Peggy, the sister he was closest to, died at the exact same age. How was he able to live that long? I’ll give you my observations based on his life.

  • Genetics: it pays to have the right genes and Dad certainly did. Several of his siblings lived into their 90s.
  • Quit smoking: he quit smoking before he turned 21 years old. That’s probably the single most important thing he did. His father and siblings who smoked all died much younger. He never drank alcohol after that either.
  • Love: he loved his wife of over 70 years deeply, and as I said Wednesday, he longed to be with Ruth again. That’s a love that transcends life itself.
  • Humor: he had a great sense of humor. He gave it and was able to take it as well. My big ears were a frequent target. Once after we came in from a run together on a cold day, he said, “I know why you wear that headband: reduce wind resistance.”
  • Demeanor: he was almost always calm and pleasant and rarely showed any anger. Paula said when she was a kid and acted up, he’d just hang his head and sigh, and that hurt worse than any spanking. Once when he was mad at me, he showed it by leaving the newspaper at the top of the steps instead of putting it on the counter. He never stayed mad long.
  • Faith: he believed in God and lived his faith.
  • Exercise: he worked physical jobs most of his life. Then he began running when he was 70 and continued until he was in his mid-80s, hitting 700 miles for 2002. No doubt that helped him live longer than he might have with a genetic tendency toward stroke. He was never very fast but once you’re over 70, there’s not a lot of competition and he enjoyed picking up trophies at many of his 5Ks. I’m sure that competitive spirit added zest to his life.
  • Body weight: he was never fat for his height. That reduced any additional stress on his joints.

Those are my observations on how Joner lived into his 90s. While you can’t change your genes, you can certainly make the most of what you’ve got; his lifestyle and approach to life certainly helped my father-in-law.

What are you prepared to do today?

Dr. Chet

 

Immune Boost 1-2-3 Cautions

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Someone recently asked an excellent question: “Is there any risk in taking higher amounts of echinacea?” I’ll extend that to include vitamin C, garlic, and probiotics. The answer is possibly. I’m not hedging, but it’s complicated. Let me give you some examples.

One factor that can apply to any supplement is allergies. Echinacea and garlic are plants, and you may be allergic to one of the components of the plant. Instead of reducing your allergic response, it may heighten the response, causing the watery eyes and runny nose you’re trying to avoid. There’s no way to know for sure other than trial and error. If something makes you feel worse, it goes without question that you’ll stop it immediately.

Another potential issue is your genetics; you may process a phytochemical from these plants faster or slower than typical. That means it could be metabolized out of your system before it really has a positive effect or it could take longer to metabolize and stay in your system longer. There are no genetic tests for how you’ll react to any supplement—it’s trial and error.

One other aspect that’s important is whether you take medications. No surprise that there’s incomplete research on the interaction of every plant with every medication, so there’s no way to know how an herb or nutrient will interact with your meds. Garlic may reduce the coagulation of your blood; if you’re on blood thinners, you may not be able to take garlic because it could thin your blood too much. Or you might be able to take it because of your genetics and how you metabolize it. See how complicated it gets?

What you should know is that most people will not have a problem using the 1-2-3 immune boost. If you do, do what any reasonable person would do and stop taking it. On Saturday, I’ll cover the issue of using echinacea if you have an autoimmune disease.

What are you prepared to do today?

Dr. Chet

 

Nutrition Can’t Fix Everything: Your Genetics

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In this final post on why nutrition can’t fix everything, let’s take a look at genetics. All things being equal, genetics—specifically minor mutations in our genes—is probably the biggest reason why nutrition can’t fix everything. Here are a few examples to explain why it can’t.

For someone with celiac disease, a genetic test can confirm the diagnosis. Once confirmed, the person should no longer eat any foods with gluten to avoid digestive issues. No other nutrient, enzyme, or probiotic can repair the gene. Nutrition can’t fix it.

In last Saturday’s message, I . . .

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