Tag Archive for: genes

Should Your DNA Guide Your Diet?

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In an opinion piece, a college professor in the U.K. who had written about personalized nutrition wanted to find out whether she should change her diet based on her genetic profile. She decided to send her DNA to Norway for analysis.

Her genetic profile indicated that she was at risk for having high cholesterol and an increased risk for cardiovascular disease. To deal with that, she became a vegetarian. She also takes high levels of B vitamins because she doesn’t process one of the B vitamins very well. Her point was that knowing her genetics gave her the motivation to take control of her diet and lifestyle. She now advocates that all of us should take control of our health through personalized nutrition based on our DNA analysis.

I’m not so sure. I think genetics are one piece of a complex puzzle. What causes the genes to express themselves? What turns them off? More than anything, what role does the microbiome play when combined with the genes? We still don’t know the answers to any of those questions.

Someday we may be at a point where we can be very specific about nutrition, but we’re not there yet because we not only don’t know the answers—we don’t know the correct questions to ask. For reliable results, it still comes down to what I always tell you: Eat better. Eat less. Move more.

What are you prepared to do today?

        Dr. Chet

Reference: http://bit.ly/2ZclpII

Genetics or Lifestyle?

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My dad died of a heart attack when he was 41. That fact has always been hanging over my head, especially when I had a heart blockage 16 years ago; the coronary artery was opened, I had a stent put in and have had no issues since. Was it my genes or was it lifestyle? Genotype or genes versus phenotype or lifestyle. I’ve always said genes, but not any more.

Researchers recently published an analysis of over 800 million individuals after examining births, deaths, and relationships between the individuals: in other words, who married whom, how many children they had, how long they lived. They found that a role for a genetic component of longevity was supported in family trees of people who were related. But here’s the interesting thing: they also found that there was a longevity relationship between non-blood relatives as well. In other words, the subjects’ in-laws shared similar traits for longevity.

What does that mean? Perhaps people unconsciously select mates with comparable traits. Because we don’t do that intentionally by genetics, it means that similar environments have a similar impact.

The actual role of genetics was estimated to be well below 10%. In other words, phenotype or lifestyle is more meaningful than your genes for how long you live. This was a very complicated mathematical analysis, so we should proceed with caution, but there’s little question that lifestyle has more to do with longevity than your genes.

Good genes give you a good start, but what you do after that matters most. What should you do? Eat better. Eat less. Move more.

Your body. Your choice. What are you prepared to do today?

Dr. Chet

 

Reference: https://doi.org/10.1534/genetics.118.301613

 

The Genetics of Smoking

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The study I’m examining this week is profound for a number of reasons. Identifying the genes that are affected by direct contact with the toxins in cigarette smoke provides one piece of a very complex puzzle. For example, they showed the difference in genetic mutations in the same type of tumors between smokers and non-smokers. The smokers had the genetic mutations while the non-smokers didn’t. So why did they get that type of cancer? That’s why I said it’s one piece of a puzzle. There are undoubtedly other factors involved.

With the information that . . .

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Smoking and Cancer Update

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A fascinating research paper was recently published in which researchers compared the genetic mutations found in 14 different types of tumors from chronic cigarette smokers and those who never smoked. They were attempting to see the differences in the genetic damage that occurred in tumors from the same organs between people who smoked and those who had never smoked. While they occur less frequently in non-smokers, some types of lung cancers still occur in those who never smoke.

This was complicated research to say the least. The research group had developed an algorithm that would look at over 90 . . .

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I’m Alive V2.47

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If you’re a long-time reader, this message may be familiar. Whenever I have a message scheduled for May 10th, I always use an updated version of the same message: 47 years ago today, my dad died at the age of 41. From the time I turned 41, every day I wake up on May 10th, I believe I have at least another year to live. It makes absolutely no sense, but it’s what I feel.

I didn’t know my dad well; my parents were divorced when I was very young. He could have seen me any . . .

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Trial and Answer for Your Health

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We are alive today because our ancestors survived. That seems like stating the obvious, but think about it for a minute. They ate whatever gave them fuel to stay alive and didn’t kill them. It was trial and error, and I’m guessing many died from eating the wrong things. They experienced times of feast and times of famine. They ate what was available whether it was meat, roots, berries, greens, or whatever. They learned to grow food, both plants and animals. Their diets ranged from high-fat and protein like the Inuit to the plant-based diets of . . .

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We Adapt

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In a recent paper in the magazine Nature, researchers compared the genes of a group of Inuit Indians, Europeans, and Chinese. As you might expect, there are many similarities. We’re all human, after all. But there were some specific differences, including an area in the genes related to the way the Inuit processed fat and the hormones they produce and how it contributes to height and weight.

The typical Inuit diet involves high amounts of fatty fish, rich in omega-3 fatty acids and protein; they don’t have access to many vegetables or fruit. We would expect this . . .

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