In
this Memo, I’ll review the third paper from the recent journal Cell on fasting
and summarize what this all may mean for the use of intermittent fasting.
Researchers
used both mice and humans as subjects in a series of studies. The objective was
to examine how the immune system responded to a fasting protocol. For the study
in humans, the subjects fasted for 19 hours after eating, with blood samples
taken before and after the fast. In the mice, a variety of protocols were used.
The most common was mice were fed for a short time before food was withheld for
the remainder of 24 hours.
In
mice and humans, circulating monocytes were reduced. This was important because
they were pro-inflammatory in nature; thus inflammation decreased in response
to the fasting protocol. In some of the studies, this reduction was maintained
even with exposure to pathogens. That means the immune response was not
compromised even in animals with induced autoimmune diseases.
Fasting
Protocols
Three different studies used
at least three different approaches to fasting. In the first study, food was
withheld completely for 36 hours. In some phases of the second study, calories
were reduced by 50% although the vitamins, minerals, and protein were
maintained at normal levels. The final study used a fasting protocol we’re most
familiar with: eat within a few hours and liquids only the remainder of the day.
The results were similar in
sustaining and perhaps improving the immune system of the animals when placed
under pathogenic stress. The only issue is what form of dietary restriction
worked best? You can’t ask mice how they felt; you can only check immune system
markers. In one of the approaches, the skin of the mice was injured at
different times of continued fasting. The healing ability continued until the
fast went beyond 48 hours; after that wound-healing was impaired.
The Bottom
Line
These
studies haven’t changed my approach to fasting. If you’re going to fast to
rejuvenate your immune system, don’t play games. Reduce caloric intake to 500 to
800 calories per day for two to three days; those studies show the best
benefit. Be sure to select small quantities of the healthiest foods.
Fasting
is not abstinence. The current approaches to intermittent fasting are really
intermittent abstinence. The idea is to abstain from food completely for 12 to 18
hours while still drinking liquids. That may not be possible for everyone. Some
medications have to be taken in relation to food intake. Pre-diabetics and type
2 diabetics should still monitor blood sugar, especially if exercising during
the fasting times. The current intermittent fasting approach is more about
controlling when you eat than anything else, and that’s something you should do
anyway.
I
believe in fasting. That’s why I wrote Real-Life Detox—so
you could do it right and gain the most benefit. The critical thing is to find
a way to eat that you can sustain for the rest of your life, and that includes
occasional fasts.
Eat
less. Eat better. Move more. That’s always the goal.
What
are you prepared to do today?
Dr. Chet
References:
1. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.047.
2. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.049.
3. Cell. 2019. DOI:https://doi.org/10.1016/j.cell.2019.07.050