Tag Archive for: CAD

Erythritol: Reserve Judgment for Now

/in /by

The study published in Nature Medicine on erythritol is complex to say the least. I gave you three quarters of the results. There was one more part that I want to cover and then give you my primary issues with the study. As I said in Tuesday’s Memo, I’ve posted a Straight Talk on Health podcast for Members and Insiders that gives my complete thoughts on sugar alcohols, especially erythritol (remember to log in first).

Erythritol and Clotting

The final part of the study was actually a preliminary report on a much larger study. They had eight subjects drink 30 grams of erythritol mixed with 300 ml of water. That corresponds to estimates of what a high intake would be. Then they tracked serum erythritol levels in the subjects for seven days. They also tested for indicators of blood clotting factors and found that some were increased for a few days after consuming the erythritol drink. The implication is that high intake of erythritol might contribute to blood clots forming. The question is: who is at risk?

Primary Issues

My primary concern is the lack of adequate controls. This was an observational study, not a clinical trial, so no cause and effect can be determined. Researchers took measurements on several cohorts of subjects with diagnosed coronary artery disease (CAD). Those subjects had a host of risk factors including high blood pressure, type 2 diabetes, high LDL- cholesterol, and on and on. The ages in each cohort ranged from a median of 65 in the Discover cohort up to 75 in the European cohort.

They did not have a comparable cohort of apparently healthy controls in the same age group. They could have chosen a group of subjects who had blood drawn at their annual physical but no apparent diagnosis of CAD. While still not getting to cause and effect, it would have strengthened the basic observations if major adverse cardiovascular events (MACE) was seen or not seen in the controls.

The same is true for the study on the erythritol drink. Why not get a group with diagnosed CAD and see if the same clotting effect happened? If not that, why not just do a simple test that measures clotting time? That’s done for anyone who takes a blood thinner such as warfarin.

The Bottom Line

The researchers called for more research on erythritol to examine the increased adverse events in the present study, and I agree. Because erythritol is part of many low-carbohydrate foods and drinks designed for diabetics and those on a ketogenic diet, we need to know more about the risks. This was a good research paper but incomplete. The best we can say as to whether we should use sugar alcohols is that we must reserve judgment until a lot more research is done.

If you’re concerned about artificial sweeteners, try to cut back and use a variety of them to reduce the risks associated with any particular one. But for your health’s sake, don’t switch to sugar; the risks of high sugar consumption are even greater than those associated with artificial sweeteners. For ideas of asking the right questions in those future trials and more on sugar alcohols, check out the Straight Talk on Health just posted by becoming a Member or Insider.

What are you prepared to do today?

        Dr. Chet

Reference: Nature Medicine. 2023. https://www.nature.com/articles/s41591-023-02223-9

How to Reverse Heart Disease

/in /by

In this final message of the week on reversing heart disease, I’m going to tell you why I think the program was successful, a couple of problems that I have with it, and the bottom line.
 
The Training
The key to this program in my opinion was education. The program began with a five-hour seminar with limited participation: no more than 12 participants. Here’s what they did in the training:

  • Explained the relationship between diet and heart disease in other cultures throughout the world.
  • Showed the damage to arteries in very young . . .

    We're sorry, but this content is available to Members and Insiders only.

    If you're already a DrChet.com Member or Insider, click on the Membership Login link on the top menu. Members may upgrade to Insider by going to the Store and clicking Membership; your membership fee will be prorated automatically.

What to Eat to Reverse Heart Disease

/in /by

We’re going to continue our look at the recently published research on the way to reverse CAD. Remember, 89% of the people recruited for this study were still following the diet more than three years later. Let’s take a look at what they ate and what they didn’t eat.

The paper describes the core diet as consisting of the following: whole grains, legumes, lentils, other vegetables, and fruit. Of course, this is a completely vegan diet. The researchers assured the subjects that they would reach their protein intake every day.

The researchers prohibited many foods as well . . .

We're sorry, but this content is available to Members and Insiders only.

If you're already a DrChet.com Member or Insider, click on the Membership Login link on the top menu. Members may upgrade to Insider by going to the Store and clicking Membership; your membership fee will be prorated automatically.

Reversing Heart Disease

/in /by

Heart disease is the leading cause of death in the U.S. and Canada in people 65 and older. Many people who are younger have high blood pressure, clogged arteries, and arrhythmias; the side effects of treating those issues impair their lives, and they can’t do all they’d like to do because of physical limitations due to coronary artery disease (CAD). But what if there were a way, without medications, without surgeries, to reverse CAD? This was the question posed in a recently published study (1) that we’ll examine this week.

The primary author is Dr. Caldwell . . .

We're sorry, but this content is available to Members and Insiders only.

If you're already a DrChet.com Member or Insider, click on the Membership Login link on the top menu. Members may upgrade to Insider by going to the Store and clicking Membership; your membership fee will be prorated automatically.