Tag Archive for: acesulfame potassium

Artificial Sweeteners and Cancer: The Bottom Line

/in /by

In the paper on artificial sweeteners and cancer risk that I covered on Tuesday, the researchers made it clear that although the study was done well, cause and effect cannot be determined. They also acknowledge that because 80% of the subjects were women, the results couldn’t be applied to the entire French population, let alone the population of any other country. What it could mean is that artificial sweeteners in combination with other dietary, environmental, or genetic factors could contribute to cancer development.

Here are some other issues with the data and the analysis:

  • They did not test the subjects for cancer before the study. They eliminated several thousand people for already having had cancer, but they didn’t check for present cancers that hadn’t reached the point where they could be diagnosed. That would have added to the complexity, but it was possible.
  • They didn’t seem to ask when the subjects began using artificial sweeteners. The mean age was 42 at the beginning of the study, so subjects might have been using them for decades; some may have been using them for only a few days. Most cancers take years to develop, so the possible link between artificial sweeteners and cancer is probably zero in people who’ve used them a short time. The real question is whether long-term users had a higher risk.
  • I would like to have seen scattergrams of artificial-sweetener intake along with fruit-and-vegetable intake on rates of cancer. In other words, could the increase in fruits and/or vegetables reduce the impact of artificial sweeteners? Fiber intake, exercise, and BMI could also have been plotted against artificial-sweetener consumption. They accounted for these statistically, but seeing what happens when plotted could show how behavioral changes might help neutralize the artificial sweeteners.
  • One thing they didn’t is factor in is use of animal products (except dairy) and the risk of cancer—the only factors accounted for were weight-loss, a healthy diet, and a Western diet. All the studies I’ve seen assess meat intake and cancer, especially processed meat.

The Bottom Line

Take this study for what it is: an indicator that there are numerous potential causes of cancers. Clinical trials can determine cause and effect if the studies are well designed. This study did a wonderful job of measuring the intake of artificial sweeteners; they just didn’t take it all the way in analyzing the data they collected.

So what should you do? If you use artificial sweeteners, that’s fine. If you prefer not to or want to cut down, that’s fine as well. There’s nothing from this study that indicates there’s anything to fear. Paula and I both use artificial sweeteners, we’ll continue to use them, and we won’t worry about them at all.

I still believe that obesity is a greater risk, not just for cancer but for many other health issues; if artificial sweeteners help you reduce or maintain your weight, I’d say the scale tips toward using them.

We’re taking next week off for spring break, so I’ll see you back here April 12. Then we’ll look at what science shows you can do to really limit your risk of cancer.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1371/journal.pmed.1003950

Do Artificial Sweeteners Increase Cancer Risk?

/in /by

Last week, my health news feed filled up with headlines that almost all sounded like this: “Artificial Sweeteners Linked to Higher Cancer Risk!” This isn’t the first study to suggest that relationship and it won’t be the last. This French epidemiological study of over 100,000 subjects collected data for more than seven years. One of the things I almost always criticize is data collection using food frequency questionnaires. Not this time.

The subjects completed at least two food diaries per year. Portions were assessed by comparing with pictures of portions sizes. What they did particularly well is to list all the foods that contained artificial sweeteners, including all brand names; then they tested most of the foods in the lab to verify the presence of artificial sweeteners. Researchers collected as many confounding variables as they could to account for everything that contributes to cancer.

After the statistical analysis, the overall hazard ratio demonstrated a 13% increase in the risk of cancer. Aspartame and acesulfame potassium were the artificial sweeteners with the highest hazard ratio among all those tested. Based on this information, do we need to avoid artificial sweeteners or at least lower the amounts we consume? I’ll talk about that Saturday.

What are you prepared to do today?

        Dr. Chet

Reference: https://doi.org/10.1371/journal.pmed.1003950

Artificial Sweeteners, Obesity, and Diabetes

/in /by

Last week, you may have seen headlines that said something like “Artificial Sweeteners May Cause Obesity and Type 2 Diabetes!” Just about every news organization picked up a press release from the Experimental Biology meeting. In the press release, researchers gave some of the results of a paper that was presented at a scientific session, including comments by the lead author, Dr. Brian R. Hoffman.

The purpose for doing the study, he said, was because of the epidemic of obesity and diabetes in the U.S. While there’s little question that excessive sugar intake, combined with excess calories over years, does contribute to obesity and type 2 diabetes, no one has really examined the role artificial sweeteners may play.

In these studies, he and his research team examined the effect of high levels of sugars, aspartame, and acesulfame potassium on epithelial cells taken from rodents in a test-tube study. Then using another group of rodents, they overfed them sugars and the same artificial sweeteners for three weeks. The objective was to see what changes occurred in proteins and metabolites that were produced in cardiovascular epithelial cells in the test-tube study and the blood of the rodents.

They found that there were modifications in proteins under both conditions, which may have led to changes in the products they produced. But is this meaningful research or not? I’ll tell you what I liked about the study in Thursday’s memo.

What are you prepared to do today?

Dr. Chet

 

Reference: EB 2018. The Influence of Sugar and Artificial Sweeteners on Vascular Health during the Onset and Progression of Diabetes Board # / Pub #: A322 603.20.