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Will Taking a Multivitamin Increase Your Risk of Death?

Close to a month ago, the health headlines were full of warnings about multivitamins. A long-time researcher even did a video to explain the study. This headline was based on a study that demonstrated an increase in Hazard Ratio if a person took a multivitamin every day, compared to occasionally or never. On the face of it, this seemed to be a compelling study. Data were combined from three large studies that totaled over 390,000 participants. The data were taken from health and nutrition questionnaires first given more than 20 years ago, with the mean follow up time of about 21 years. The questionnaires asked about a variety of demographic data as well as health and nutrition habits; the nutrition data were the old-style FFQ form.

After analyzing the data, researchers found a 4% increase in mortality risk in those participants who took a multivitamin every day compared to those who did not. Should you be worried? Aside from the number of covariates they considered, and you know how those combinations can add up, there were at least two problems. I’ll cover those on Saturday.

The Winners of the Challenge

Everyone who responded to the 4th of July challenge did an amazing job—no one had fewer than 20 vegetables and fruits. Where it got a little murky was in the herbs and spices; I’ll take the blame for that as I didn’t explain it as well as I should. For the overall total, I’m going to declare a tie between RE and KB; they each had close to 60 foods that qualified! For vegetables alone, VK topped the list with 23 and MW topped the fruit list with 13. Great job, everybody!

What are you prepared to do today?

        Dr. Chet

Reference: JAMA Network Open. 2024;7(6):e2418729.